Medical Hypothesis : Prevention of Cerebrovascular Disease by "Hypoxic Training in a Hypoxic Chamber", Based on the Theory of Ischemic Preconditioning(Special Issue in Hornor of the Retirement of Professor Makoto Iwata at the Department of Neurology, Tokyo Women\u27s Medical University)

Sublethal tissue ischemia (hypoxic stress) provides tolerance to subsequent ischemic insults. This phenomenon is known as ischemic preconditioning. At high-altitude, a dynamic autoregulation mechanism occurs to maintain homeostasis in the body. In terms of ischemic preconditioning, various physiological, cellular and molecular adaptations occur at high altitude to maintain homeostasis, including the alteration of the vascular system (vasodilation) and the induction of anti-apoptosis gene expression. In this review article, I will perform a literature review on ischemic preconditioning in the field of clinical neurology, and discuss the putative role of ischemic preconditioning approach to prevent cerebrovascular disease. In addition to Cerebrovascular disease, "Hypoxic training performed in a hypoxic chamber" may be extended to prevention of other hypoxia-related conditions such as ischemic heart diseases.神経内科学教室岩田誠教授退任記念特別